Developing A Community-based Genetic Nomenclature for Anole Lizards

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Developing A Community-based Genetic Nomenclature for Anole Lizards

Show simple item record Kusumi, Kenro Kulathinal, Rob J. Abzhanov, Arkhat Boissinot, Stephane Crawford, Nicholas Faircloth, Brant C. Glenn, Travis C. Janes, Daniel E. Losos, Jonathan Menke, Douglas B. Poe, Steven Sanger, Thomas Schneider, Christopher Stapley, Jessica Wade, Juli Wilson-Rawls, Jeanne 2012-08-27T19:55:31Z 2011
dc.identifier.citation Kusumi, Kenro, Rob J. Kulathinal, Arhat Abzhanov, Stephane Boissinot, Nicholas G. Crawford, Brant C. Faircloth, Travis C. Glenn et al. 2011. Developing a community-based genetic nomenclature for anole lizards. BMC Genomics 12: 554. en_US
dc.identifier.issn 1471-2164 en_US
dc.description.abstract Background: Comparative studies of amniotes have been hindered by a dearth of reptilian molecular sequences. With the genomic assembly of the green anole, Anolis carolinensis available, non-avian reptilian genes can now be compared to mammalian, avian, and amphibian homologs. Furthermore, with more than 350 extant species in the genus Anolis, anoles are an unparalleled example of tetrapod genetic diversity and divergence. As an important ecological, genetic and now genomic reference, it is imperative to develop a standardized Anolis gene nomenclature alongside associated vocabularies and other useful metrics. Results: Here we report the formation of the Anolis Gene Nomenclature Committee (AGNC) and propose a standardized evolutionary characterization code that will help researchers to define gene orthology and paralogy with tetrapod homologs, provide a system for naming novel genes in Anolis and other reptiles, furnish abbreviations to facilitate comparative studies among the Anolis species and related iguanid squamates, and classify the geographical origins of Anolis subpopulations. Conclusions: This report has been generated in close consultation with members of the Anolis and genomic research communities, and using public database resources including NCBI and Ensembl. Updates will continue to be regularly posted to new research community websites such as lizardbase. We anticipate that this standardized gene nomenclature will facilitate the accessibility of reptilian sequences for comparative studies among tetrapods and will further serve as a template for other communities in their sequencing and annotation initiatives. en_US
dc.description.sponsorship Organismic and Evolutionary Biology en_US
dc.description.sponsorship Other Research Unit en_US
dc.language.iso en_US en_US
dc.publisher BioMed Central en_US
dc.relation.isversionof doi:10.1186/1471-2164-12-554 en_US
dash.license LAA
dc.title Developing A Community-based Genetic Nomenclature for Anole Lizards en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal BMC Genomics en_US Losos, Jonathan 2012-08-27T19:55:31Z

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