dc.contributor.author | Burbank, Kendra Stewart | |
dc.contributor.author | Kreiman, Gabriel | |
dc.date.accessioned | 2012-09-25T17:41:08Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Burbank, Kendra S., and Gabriel Kreiman. 2012. Depression-biased reverse plasticity rule is required for stable learning at top-down connections. PLoS Computational Biology 8(3): e1002393. | en_US |
dc.identifier.issn | 1553-734X | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:9637989 | |
dc.description.abstract | Top-down synapses are ubiquitous throughout neocortex and play a central role in cognition, yet little is known about their development and specificity. During sensory experience, lower neocortical areas are activated before higher ones, causing top-down synapses to experience a preponderance of post-synaptic activity preceding pre-synaptic activity. This timing pattern is the opposite of that experienced by bottom-up synapses, which suggests that different versions of spike-timing dependent synaptic plasticity (STDP) rules may be required at top-down synapses. We consider a two-layer neural network model and investigate which STDP rules can lead to a distribution of top-down synaptic weights that is stable, diverse and avoids strong loops. We introduce a temporally reversed rule (rSTDP) where top-down synapses are potentiated if post-synaptic activity precedes pre-synaptic activity. Combining analytical work and integrate-and-fire simulations, we show that only depression-biased rSTDP (and not classical STDP) produces stable and diverse top-down weights. The conclusions did not change upon addition of homeostatic mechanisms, multiplicative STDP rules or weak external input to the top neurons. Our prediction for rSTDP at top-down synapses, which are distally located, is supported by recent neurophysiological evidence showing the existence of temporally reversed STDP in synapses that are distal to the post-synaptic cell body. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Public Library of Science | en_US |
dc.relation.isversionof | doi:10.1371/journal.pcbi.1002393 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291526/pdf/ | en_US |
dash.license | LAA | |
dc.title | Depression-Biased Reverse Plasticity Rule Is Required for Stable Learning at Top-down Connections | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | PLoS Computational Biology | en_US |
dash.depositing.author | Kreiman, Gabriel | |
dc.date.available | 2012-09-25T17:41:08Z | |
dc.identifier.doi | 10.1371/journal.pcbi.1002393 | * |
dash.contributor.affiliated | Burbank, Kendra Stewart | |
dash.contributor.affiliated | Kreiman, Gabriel | |