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dc.contributor.authorGray, L.
dc.contributor.authorLee, I-Min
dc.contributor.authorSesso, Howard David
dc.contributor.authorBatty, G. D.
dc.date.accessioned2012-10-22T16:53:29Z
dc.date.issued2012
dc.identifier.citationGray, L., I-M. Lee, H. D. Sesso, and G. D. Batty. 2012. Association of body mass index in early adulthood and middle age with future site-specific cancer mortality: The Harvard Alumni Health Study. Annals of Oncology 23(3): 754-759.en_US
dc.identifier.issn0923-7534en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:9793860
dc.description.abstractBackground:: The association between adiposity in early adulthood and subsequent development of specific malignancies is unclear. Further, the potential for mediation by adiposity in middle age has not been well examined. In a rare study, we investigated the association of body mass index (BMI) in early adulthood with mortality from several site-specific cancers. Design: In the Harvard Alumni Health Study cohort, 19 593 males had a physical examination at the university between 1914 and 1952 (mean age: 18.4 years) and returned a questionnaire in 1962 or 1966 (mean age = 45.1 years). BMI was computed using weight (kg)/\(height^2\) (\(m^2\)) at both time points. Vital status follow up continued for a maximum of 82 years. Results: Positive early adulthood cancer mortality gradients by BMI were found for all malignancies combined (adjusted hazard ratio [HR] = 1.11; 95% confidence interval [CI]: 1.05–1.17 for a one standard deviation increase in early adulthood BMI), and for lung (HR = 1.24; 95% CI = 1.10–1.40) and skin (HR = 1.29; 95% CI = 0.96–1.75) cancers. There were also apparent associations for cancers of the oesophagus and urogenital sites. Mediation by BMI in middle age was found to be minimal. Conclusion: Higher BMI in early adulthood appears to be a direct risk factor for selected malignancies several decades later.en_US
dc.language.isoen_USen_US
dc.publisherOxford University Pressen_US
dc.relation.isversionofdoi:10.1093/annonc/mdr270en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331729/pdf/en_US
dash.licenseLAA
dc.subjectepidemiologyen_US
dc.subjectbody mass indexen_US
dc.subjectHarvarden_US
dc.subjectcohort studyen_US
dc.subjectmortalityen_US
dc.titleAssociation of Body Mass Index in Early Adulthood and Middle Age with Future Site-Specific Cancer Mortality: The Harvard Alumni Health Studyen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalAnnals of Oncologyen_US
dash.depositing.authorSesso, Howard David
dc.date.available2012-10-22T16:53:29Z
dc.identifier.doi10.1093/annonc/mdr270*
dash.contributor.affiliatedLee, I-Min
dash.contributor.affiliatedSesso, Howard


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