A High Resolution Map of a Cyanobacterial Transcriptome

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A High Resolution Map of a Cyanobacterial Transcriptome

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Title: A High Resolution Map of a Cyanobacterial Transcriptome
Author: O'Shea, Erin K; Vijayan, Vikram; Jain, Isha Himani

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Citation: Vijayan, Vikram, Isha H. Jain, and Erin K. O'Shea. 2012. A high resolution map of a cyanobacterial transcriptome. Genome Biology 12(5): R47.
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Abstract: Background: Previous molecular and mechanistic studies have identified several principles of prokaryotic transcription, but less is known about the global transcriptional architecture of bacterial genomes. Here we perform a comprehensive study of a cyanobacterial transcriptome, that of Synechococcus elongatus PCC 7942, generated by combining three high-resolution data sets: RNA sequencing, tiling expression microarrays, and RNA polymerase chromatin immunoprecipitation sequencing. Results: We report absolute transcript levels, operon identification, and high-resolution mapping of 5' and 3' ends of transcripts. We identify several interesting features at promoters, within transcripts and in terminators relating to transcription initiation, elongation, and termination. Furthermore, we identify many putative non-coding transcripts. Conclusions: We provide a global analysis of a cyanobacterial transcriptome. Our results uncover insights that reinforce and extend the current views of bacterial transcription.
Published Version: doi:10.1186/gb-2011-12-5-r47
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:9793865
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