Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function

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Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function

Show simple item record Pattaro, Cristian Köttgen, Anna Teumer, Alexander Böger, Carsten A. Fuchsberger, Christian Olden, Matthias Chen, Ming-Huei Tin, Adrienne Taliun, Daniel Li, Man Gao, Xiaoyi Gorski, Mathias Yang, Qiong Hundertmark, Claudia Foster, Meredith C. Glazer, Nicole Isaacs, Aaron Liu, Ching-Ti Smith, Albert V. O'Connell, Jeffrey R. Struchalin, Maksim Tanaka, Toshiko Gierman, Hinco J. Feitosa, Mary Hwang, Shih-Jen Atkinson, Elizabeth J. Lohman, Kurt Johansson, Åsa Tönjes, Anke Dehghan, Abbas Chouraki, Vincent Holliday, Elizabeth G. Sorice, Rossella Kutalik, Zoltan Lehtimäki, Terho Esko, Tõnu Deshmukh, Harshal Ulivi, Sheila Murgia, Federico Trompet, Stella Imboden, Medea Kollerits, Barbara Pistis, Giorgio Harris, Tamara B. Launer, Lenore J. Aspelund, Thor Eiriksdottir, Gudny Mitchell, Braxton D. Boerwinkle, Eric Schmidt, Helena Cavalieri, Margherita Rao, Madhumathi Demirkan, Ayse Oostra, Ben A. de Andrade, Mariza Ding, Jingzhong Andrews, Jeanette S. Freedman, Barry I. Koenig, Wolfgang Illig, Thomas Döring, Angela Wichmann, H.-Erich Kolcic, Ivana Zemunik, Tatijana Boban, Mladen Minelli, Cosetta Wheeler, Heather E. Igl, Wilmar Zaboli, Ghazal Wild, Sarah H. Wright, Alan F. Campbell, Harry Ellinghaus, David Nöthlings, Ute Jacobs, Gunnar Biffar, Reiner Endlich, Karlhans Ernst, Florian Homuth, Georg Kroemer, Heyo K. Nauck, Matthias Stracke, Sylvia Völker, Uwe Völzke, Henry Kovacs, Peter Stumvoll, Michael Mägi, Reedik Uitterlinden, Andre G. Rivadeneira, Fernando Aulchenko, Yurii S. Polasek, Ozren Hastie, Nick Vitart, Veronique Helmer, Catherine Wang, Jie Jin Ruggiero, Daniela Bergmann, Sven Kähönen, Mika Viikari, Jorma Nikopensius, Tiit Province, Michael Ketkar, Shamika Colhoun, Helen Doney, Alex Robino, Antonietta Giulianini, Franco Krämer, Bernhard K. Portas, Laura Ford, Ian Buckley, Brendan M. Adam, Martin Thun, Gian-Andri Paulweber, Bernhard Haun, Margot Sala, Cinzia Metzger, Marie Mitchell, Paul Ciullo, Marina Kim, Stuart K. Vollenweider, Peter Raitakari, Olli Metspalu, Andres Palmer, Colin Gasparini, Paolo Pirastu, Mario Jukema, J. Wouter Probst-Hensch, Nicole M. Kronenberg, Florian Toniolo, Daniela Gudnason, Vilmundur Shuldiner, Alan R. Coresh, Josef Schmidt, Reinhold Ferrucci, Luigi Siscovick, David S. van Duijn, Cornelia M. Borecki, Ingrid Kardia, Sharon L. R. Liu, Yongmei Rudan, Igor Gyllensten, Ulf Wilson, James F. Franke, Andre Pramstaller, Peter P. Rettig, Rainer Prokopenko, Inga Witteman, Jacqueline C. M. Hayward, Caroline Parsa, Afshin Bochud, Murielle Heid, Iris M. Garnaas, Maija O'Seaghdha, Conall Li, Guo Johnson, Andrew D. Cornelis, Marilyn Chu, Audrey Yu-lei Hu, Frank B. Turner, Stephen T. Hofman, Albert Curhan, Gary Craig Ridker, Paul M. Goessling, Wolfram Chasman, Daniel Ian Kao, W. H. Linda Fox, Caroline 2012-10-23T15:17:08Z 2012
dc.identifier.citation Pattaro, Cristian, Anna Köttgen, Alexander Teumer, Maija Garnaas, Carsten A. Böger, Christian Fuchsberger, Matthias Olden, et al. 2012. Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genetics 8(3): e1002584. en_US
dc.identifier.issn 1553-7390 en_US
dc.description.abstract Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near \(MPPED2\), \(DDX1\), \(SLC47A1\), \(CDK12\), \(CASP9\), and \(INO80\). Morpholino knockdown of \(mpped2\) and \(casp9\) in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. By providing new insights into genes that regulate renal function, these results could further our understanding of the pathogenesis of CKD. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof doi:10.1371/journal.pgen.1002584 en_US
dc.relation.hasversion en_US
dash.license LAA
dc.subject biology en_US
dc.subject genetics en_US
dc.title Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS Genetics en_US O'Seaghdha, Conall 2012-10-23T15:17:08Z

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