Amerind Ancestry, Socioeconomic Status and the Genetics of Type 2 Diabetes in a Colombian Population

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Amerind Ancestry, Socioeconomic Status and the Genetics of Type 2 Diabetes in a Colombian Population

Show simple item record Campbell, Desmond D. Parra, Maria V. Duque, Constanza Gallego, Natalia Franco, Liliana Hünemeier, Tábita Bortolini, Cátira Villegas, Alberto Bedoya, Gabriel McCarthy, Mark I. Ruiz-Linares, Andrés Tandon, Arti Price, Alkes Reich, David Emil 2012-10-26T15:24:13Z 2012
dc.identifier.citation Campbell, Desmond D., Maria V. Parra, Constanza Duque, Natalia Gallego, Liliana Franco, Arti Tandon, Tábita Hünemeier, et al. 2012. Amerind ancestry, socioeconomic status and the genetics of type 2 diabetes in a Colombian population. PLoS ONE 7(4): e33570. en_US
dc.identifier.issn 1932-6203 en_US
dc.description.abstract The “thrifty genotype” hypothesis proposes that the high prevalence of type 2 diabetes (T2D) in Native Americans and admixed Latin Americans has a genetic basis and reflects an evolutionary adaptation to a past low calorie/high exercise lifestyle. However, identification of the gene variants underpinning this hypothesis remains elusive. Here we assessed the role of Native American ancestry, socioeconomic status (SES) and 21 candidate gene loci in susceptibility to T2D in a sample of 876 T2D cases and 399 controls from Antioquia (Colombia). Although mean Native American ancestry is significantly higher in T2D cases than in controls (32% v 29%), this difference is confounded by the correlation of ancestry with SES, which is a stronger predictor of disease status. Nominally significant association (P<0.05) was observed for markers in: TCF7L2, RBMS1, CDKAL1, ZNF239, KCNQ1 and TCF1 and a significant bias (P<0.05) towards OR>1 was observed for markers selected from previous T2D genome-wide association studies, consistent with a role for Old World variants in susceptibility to T2D in Latin Americans. No association was found to the only known Native American-specific gene variant previously associated with T2D in a Mexican sample (rs9282541 in ABCA1). An admixture mapping scan with 1,536 ancestry informative markers (AIMs) did not identify genome regions with significant deviation of ancestry in Antioquia. Exclusion analysis indicates that this scan rules out ∼95% of the genome as harboring loci with ancestry risk ratios >1.22 (at P < 0.05). en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof doi:10.1371/journal.pone.0033570 en_US
dc.relation.hasversion en_US
dash.license LAA
dc.subject biology en_US
dc.subject genetics en_US
dc.subject population genetics en_US
dc.subject gene flow en_US
dc.subject genetics of disease en_US
dc.subject genome-wide association studies en_US
dc.subject human genetics en_US
dc.subject medicine en_US
dc.subject endocrinology en_US
dc.subject diabetic endocrinology en_US
dc.subject diabetes mellitus type 2 en_US
dc.subject global health en_US
dc.subject non-clinical medicine en_US
dc.subject socioeconomic aspects of health en_US
dc.title Amerind Ancestry, Socioeconomic Status and the Genetics of Type 2 Diabetes in a Colombian Population en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS ONE en_US Tandon, Arti 2012-10-26T15:24:13Z

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