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dc.contributor.authorBaker, Meghan Ann
dc.contributor.authorWilson, Douglas
dc.contributor.authorWallengren, Kristina
dc.contributor.authorSandgren, Andreas
dc.contributor.authorIartchouk, Oleg
dc.contributor.authorBroodie, Nisha Monique
dc.contributor.authorGoonesekera, Sunali D.
dc.contributor.authorSabeti, Pardis Christine
dc.contributor.authorMurray, Megan Blanche
dc.date.accessioned2012-11-13T19:02:52Z
dc.date.issued2012
dc.identifier.citationBaker, Meghan Ann, Douglas Wilson, Kristina Wallengren, Andreas Sandgren, Oleg Iartchouk, Nisha Broodie, Sunali D. Goonesekra, Pardis C Sabeti, and Megan B. Murray. 2012. Polymorphisms in the gene that encodes the iron transport protein ferroportin 1 influence susceptibility to suberculosis. Journal of Infectious Disease 205(7): 1043-1047.en_US
dc.identifier.issn0022-1899en_US
dc.identifier.issn1537-6613en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:9891821
dc.description.abstractBackground: We studied the association between iron intake and polymorphisms in the iron transporter gene, SLC40A1, and the risk of tuberculosis. Methods: We compared iron intake, the frequency of SLC40A1 mutations, and interactions between these variables among 98 TB patients and 125 controls in Kwazulu-Natal, South Africa. Results: Four SLC40A1 SNPs were associated with an increased risk of tuberculosis and one with reduced risk. We also found a gene-environment interaction for four non-exonic SNPs and iron intake. Conclusions: This pilot study demonstrated an association between polymorphisms in SLC40A1 and tuberculosis and provided evidence for an interaction between dietary iron and SLC40A1.en_US
dc.description.sponsorshipOrganismic and Evolutionary Biologyen_US
dc.language.isoen_USen_US
dc.publisherOxford University Pressen_US
dc.relation.isversionofdoi:10.1093/infdis/jis026en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pubmed/22357659en_US
dash.licenseOAP
dc.subjectSLC40A1en_US
dc.subjectferroportinen_US
dc.subjectFPN1en_US
dc.subjecttuberculosisen_US
dc.subjectmycobacteriumen_US
dc.subjectironen_US
dc.subjectgeneticen_US
dc.subjectsingle nucleotide polymorphismen_US
dc.subjectgene-environmenten_US
dc.titlePolymorphisms in the Gene That Encodes the Iron Transport Protein Ferroportin 1 Influence Susceptibility to Tuberculosisen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalJournal of Infectious Diseaseen_US
dash.depositing.authorSabeti, Pardis Christine
dc.date.available2012-11-13T19:02:52Z
dc.identifier.doi10.1093/infdis/jis026*
dash.authorsorderedfalse
dash.contributor.affiliatedBroodie, Nisha Monique
dash.contributor.affiliatedBaker, Meghan
dash.contributor.affiliatedMurray, Megan
dash.contributor.affiliatedSabeti, Pardis


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