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dc.contributor.advisorRitter, Tobias
dc.contributor.authorLiang, Theresa
dc.date.accessioned2012-11-14T14:19:09Z
dc.date.issued2012-11-14
dc.date.submitted2012
dc.identifier.citationLiang, Theresa. 2012. Silver-Mediated Trifluoromethoxylation of Aryl Nucleophiles and Synthesis of 3-Deoxy-3-Fluoromorphine. Doctoral dissertation, Harvard University.en_US
dc.identifier.otherhttp://dissertations.umi.com/gsas.harvard:10547en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:9904007
dc.description.abstractFluorine incorporation has become increasingly important in pharmaceutical applications. Upon fluorination and incorporation of fluorinated moieties such as trifluoromethoxy groups, many small molecules become more bioavailable and metabolically stable and additionally can better cross the blood-brain-barrier. This thesis describes the development of a method mediated by silver salts for the synthesis of pharmaceutical-like trifluoromethoxylated compounds via \(C-OCF_3\) bond formation. Additionally the synthesis of 3-deoxy-3-fluoromorphine via late-stage fluorination of morphine is described as well as in vitro and in vivo evaluation of 3-deoxy-3-fluoromorphine as a potential analgesic.en_US
dc.description.sponsorshipChemistry and Chemical Biologyen_US
dc.language.isoen_USen_US
dash.licenseLAA
dc.subjectantinociceptionen_US
dc.subjectaryl trifluoromethyl ethersen_US
dc.subjectcross-couplingen_US
dc.subjectfluorinated morphineen_US
dc.subjectsilver-mediateden_US
dc.subjecttrifluoromethoxylationen_US
dc.subjectchemistryen_US
dc.titleSilver-Mediated Trifluoromethoxylation of Aryl Nucleophiles and Synthesis of 3-Deoxy-3-Fluoromorphineen_US
dc.typeThesis or Dissertationen_US
dash.depositing.authorLiang, Theresa
dc.date.available2012-11-14T14:19:09Z
thesis.degree.date2012en_US
thesis.degree.disciplineChemistryen_US
thesis.degree.grantorHarvard Universityen_US
thesis.degree.leveldoctoralen_US
thesis.degree.namePh.D.en_US
dc.contributor.committeeMemberJacobsen, Ericen_US
dc.contributor.committeeMemberBetley, Theodoreen_US
dash.contributor.affiliatedLiang, Theresa


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