Meyer, Mara S.Joshipura, KaumudiGiovannucci, EdwardMichaud, Dominique S.2019-09-232008Meyer, Mara S., Kaumudi Joshipura, Edward Giovannucci, and Dominique S. Michaud. 2008. “A Review of the Relationship between Tooth Loss, Periodontal Disease, and Cancer.” Cancer Causes & Control 19 (9): 895–907. https://doi.org/10.1007/s10552-008-9163-4.0957-52431573-7225http://nrs.harvard.edu/urn-3:HUL.InstRepos:41392069Recent studies have investigated the association between periodontal disease, tooth loss, and several systemic diseases including cancer, cardiovascular disease, and preterm birth. Periodontal disease, a chronic inflammatory condition, is highly prevalent in adult populations around the world, and may be preventable. Estimates of prevalence vary between races and geographic regions, with a marked increase in the occurrence of periodontal disease with advancing age. Worldwide estimates for the prevalence of severe periodontal disease generally range from 10 to 15%. The relationship between oral health and cancer has been examined for a number of specific cancer sites. Several studies have reported associations between periodontal disease or tooth loss and risk of oral, upper gastrointestinal, lung, and pancreatic cancer in different populations. In a number of studies, these associations persisted after adjustment for major risk factors, including cigarette smoking and socioeconomic status. This review provides a summary of these findings, discusses possible biological mechanisms involved, and raises methodological issues related to studying these relationships.en-USJournal Article2019-09-2310.1007/s10552-008-9163-4