Portnoy, AllisonPedersen, KineKim, Jane JBurger, Emily A.2024-10-042024-04-20Portnoy, A., Pedersen, K., Kim, J.J. et al. Vaccination and screening strategies to accelerate cervical cancer elimination in Norway: a model-based analysis. Br J Cancer 130, 1951–1959 (2024). https://doi.org/10.1038/s41416-024-02682-y0007-09201532-1827https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37379576Background: Experts have proposed an ‘EVEN FASTER’ concept targeting age-groups maintaining circulation of human papillomavirus (HPV). We explored effects of the vaccination component of these proposals compared with cervical cancer (CC) screening-based interventions on age-standardized incidence rate (ASR) and CC elimination (<4 cases/100,000) timing in Norway. Methods: We used a model-based approach to evaluate HPV vaccination and CC screening scenarios compared with a status-quo scenario reflecting previous vaccination and screening. For cohorts ages 25–30 years, we examined 6 vaccination scenarios that incrementally increased vaccination coverage from current cohort-specific rates. Each vaccination scenario was coupled with three screening strategies that varied screening frequency. Additionally, we included 4 scenarios that alternatively increased screening adherence. Population- and cohort-level outcomes included ASR, lifetime risk of CC, and colposcopy referrals. Results: Several vaccination strategies coupled with de-intensified screening frequencies lowered ASR, but did not accelerate CC elimination. Alternative strategies that increased screening adherence could both accelerate elimination and improve ASR. Conclusions: The vaccination component of an ‘EVEN FASTER’ campaign is unlikely to accelerate CC elimination in Norway but may reduce population-level ASR. Alternatively, targeting under- and never-screeners may both eliminate CC faster and lead to greater health benefits compared with vaccination-based interventions we considered.en-USJournal Article2024-10-0410.1038/s41416-024-02682-y