Hou, Steven X.Goldstein, Elliott S.Perrimon, Norbert2022-07-151997-07-01Hou, Steven X., Elliott S. Goldstein, Norbert Perrimon. "Drosophila Jun Relays the Jun Amino-Terminal Kinase Signal Transduction Pathway to the Decapentaplegic Signal Transduction Pathway in Regulating Epithelial Cell Sheet Movement." Genes & Development 11, no. 13 (1997): 1728-1737. DOI: 10.1101/gad.11.13.17280890-93691549-5477https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37372607We have characterized mutations in the Drosophila homolog of the mammalian proto-oncogene c-Jun gene (Djun). We demonstrate that DJUN in the embryo is a downstream target of the JNK signal transduction pathway during dorsal closure formation, and that the function of the JNK/DJUN pathway is to control the localized expression of decapentalegic (dpp), a member of the TGF-beta growth factor family. In contrast to previous observations, we find that both in the embryo and during photoreceptor cell determination, DJUN is not regulated by a pathway that involves MAPK.en-USResearch Subject Categories::NATURAL SCIENCES::Biology::Organism biology::Developmental biologyJournal Article2022-07-1510.1101/gad.11.13.1728