Sankaran, Vijay GPoeschla, Michael2026-06-0920262026-06-052026Poeschla, Michael. 2026. Genetic Variation and Hematopoiesis. Doctoral Dissertation, Harvard University Graduate School of Arts and Sciences.32702014https://dash.harvard.edu/handle/1/42740367In this dissertation, I leverage common, rare, and somatic genetic variation to address important problems in hematopoietic biology, including the role of polygenic modifiers in variable expressivity of telomere biology disorders, the genetics and clonal dynamics of acute myeloid leukemia, and common and rare variant contributions to clonal hematopoiesis and its progression to malignancy.application/pdfenBioinformaticsGeneticsThesis or Dissertation2026-06-090009-0000-9009-4554