Inouye, SharonMarcantonio, EdwardKosar, Cyrus M.Tommet, DouglasSchmitt, Eva M.Travison, ThomasSaczynski, Jane S.Ngo, LongAlsop, DavidJones, Richard N.2022-07-192016-07Inouye, Sharon, Edward Marcantonio, Cyrus M. Kosar, Douglas Tommet, Eva M. Schmitt, Thomas Travison, Jane S. Saczynski et al. "The Short-Term and Long-Term Relationship Between Delirium and Cognitive Trajectory in Older Surgical Patients." Alzheimer's & Dementia 12, no. 7 (2016): 766-775. DOI: 10.1016/j.jalz.2016.03.0051552-52601552-5279https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37372649INTRODUCTION Since the relationship between delirium and long-term cognitive decline has not been well-explored, we evaluated this association in a prospective study. METHODS SAGES is an on-going study involving 560 adults age 70+ without dementia scheduled for major surgery. Delirium was assessed daily in the postoperative period using the Confusion Assessment Method. General Cognitive Performance (GCP) and the Informant Questionnaire for Cognitive Decline in the Elderly (IQCODE) were assessed preoperatively then repeatedly out to 36 months. RESULTS On average, patients with post-operative delirium had significantly lower preoperative cognitive performance, greater immediate (1 month) impairment, equivalent recovery at 2 months, and significantly greater long-term cognitive decline relative to the non-delirium group. Proxy reports corroborated the clinical significance of the long-term cognitive decline in delirious patients. DISCUSSION Cognitive decline following surgery is biphasic and accelerated among persons with delirium. The pace of long-term decline is similar to that seen with Mild Cognitive Impairment.en-USResearch Subject Categories::MEDICINE::Morphology, cell biology, pathology::Cell biology::NeuroscienceResearch Subject Categories::MEDICINE::Dermatology and venerology,clinical genetics, internal medicine::Internal medicine::Geriatrics and medical gerontologyJournal Article2022-07-1910.1016/j.jalz.2016.03.005