Liu, KathyBritton, Lorena M2026-01-1320252025-12-092025Britton, Lorena M. 2025. Visualization of Entangled Hydrogel Granules for Injectable Gel Therapies. Bachelors Thesis, Harvard University Engineering and Applied Sciences.32113213https://dash.harvard.edu/handle/1/42725000Injectable hydrogels show promise for minimally invasive medical treatments, but current granular hydrogels often disintegrate post-injection, limiting their clinical effectiveness. Novel entangled U-shaped granule hydrogels have been developed to address this challenge, potentially enhancing applications in cell behavior modulation, drug delivery, and non-invasive surgery. However, to optimize these gels for specific medical uses, a method to visualize and quantify their 3D microstructure is needed. This project aims to develop a software tool that produces 3D reconstructions of these hydrogels and quantifies key characteristics such as void fraction, pore size distribution, and number of entanglements.application/pdfenBioengineeringThesis or Dissertation2026-01-130009-0002-4714-0900