Qiao, Shuo-WangKobayashi, KannaJohansen, Finn-EirikSollid, Ludvig M.Andersen, Jan TerjeMilford, EdgarRoopenian, Derry C.Lencer, Wayne I.Blumberg, Richard S.2019-10-052008Qiao, S.-W., K. Kobayashi, F.-E. Johansen, L. M. Sollid, J. T. Andersen, E. Milford, D. C. Roopenian, W. I. Lencer, and R. S. Blumberg. 2008. “Dependence of Antibody-Mediated Presentation of Antigen on FcRn.” Proceedings of the National Academy of Sciences 105 (27): 9337–42. https://doi.org/10.1073/pnas.0801717105.0027-84240744-28311091-6490http://nrs.harvard.edu/urn-3:HUL.InstRepos:41483440The neonatal Fc receptor for IgG (FcRn) is a distant member of the MHC class I protein family. It binds IgG and albumin in a pH-dependent manner and protects these from catabolism by diverting them from a degradative fate in lysosomes. In addition, FcRn-mediated IgG transport across epithelial barriers is responsible for the transmission of IgG from mother to infant and can also enhance IgG-mediated antigen uptake across mucosal epithelia. We now show a previously undescribed role for FcRn in mediating the presentation of antigens by dendritic cells when antigens are present as a complex with antibody by uniquely directing multimeric immune complexes, but not monomeric IgG, to lysosomes.en-USJournal Article2019-10-0510.1073/pnas.0801717105