Lee, J. E.Hunter, D. J.Spiegelman, D.Adami, H.-O.Albanes, D.Bernstein, L.van den Brandt, P. A.Buring, J. E.Cho, E.Folsom, A. R.Freudenheim, J. L.Giovannucci, E.Graham, S.Horn-Ross, P. L.Leitzmann, M. F.McCullough, M. L.Miller, A. B.Parker, A. S.Rodriguez, C.Rohan, T. E.Schatzkin, A.Schouten, L. J.Virtanen, M.Willett, WalterWolk, A.Zhang, S. M.Smith-Warner, S. A.2019-09-212007Lee, J. E., D. J. Hunter, D. Spiegelman, H.-O. Adami, D. Albanes, L. Bernstein, P. A. van den Brandt, et al. 2007. “Alcohol Intake and Renal Cell Cancer in a Pooled Analysis of 12 Prospective Studies.” JNCI Journal of the National Cancer Institute 99 (10): 801–10. https://doi.org/10.1093/jnci/djk181.0027-88740198-01571460-2105http://nrs.harvard.edu/urn-3:HUL.InstRepos:41384674Background: The association between alcohol intake and risk of renal cell cancer has been inconsistent in case-control studies. An inverse association between alcohol intake and risk of renal cell cancer has been suggested in a few prospective studies, but each of these studies included a small number of cases. Methods: We performed a pooled analysis of 12 prospective studies that included 530469 women and 229575 men with maximum follow-up times of 7-20 years. All participants had completed a validated food-frequency questionnaire at baseline. Using the primary data from each study, the study-specific relative risks (RRs) for renal cell cancer were calculated using Cox proportional hazards models and then pooled using a random-effects model. All statistical tests were two-sided. Results: A total of 1430 (711 women and 719 men) cases of incident renal cell cancer were identified. The study-standardized incidence rates of renal cell cancer were 23 per 100000 person-years among nondrinkers and 15 per 100000 person-years among those who drank 15 g/day or more of alcohol. Compared with non-drinking, alcohol consumption (>= 15 g/day, equivalent to slightly more than one alcoholic drink per day) was associated with a decreased risk of renal cell cancer (pooled multivariable RR = 0.72, 95% confidence interval = 0.60 to 0.86; P-trend <.001); statistically significant inverse trends with increasing intake were seen in both women and men. No difference by sex was observed (P-heterogeneity = .89). Associations between alcohol intake and renal cell cancer were not statistically different across alcoholic beverage type (beer versus wine versus liquor) (P = .40). Conclusion: Moderate alcohol consumption was associated with a lower risk of renal cell cancer among both women and men in this pooled analysis.en-USJournal Article2019-09-2110.1093/jnci/djk181