Zhao, WenLiu, YuyingCahill, CatherineYang, WenluRogers, JackHuang, Xudong2022-06-292009-05-20Zhao, Wen, Yuying Liu, Catherine Cahill, Wenlu Yang, Jack Rogers, Xudong Huang. "The Role of T Cells in Osteoporosis, an Update." International Journal of Clinical and Experimental Pathology 2, no. 6 (2009): 544-552.1936-2625https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37372447Emerging evidence highlights the importance of the interplay between the bone and immune systems. That evidence bolsters a longstanding recognition that estrogen deficiency, infection, inflammation, and autoimmune disorders are associated with systemic and local bone loss. Yet, only recently has an understanding emerged that T lymphocytes and their products act as key regulators of osteoclast formation, life span, and activity. This review presents this understanding of the process of T lymphocytes and their products mediating osteoporosis and explores some of the most recent findings and hypotheses to explain their action in bone. A more complete appreciation of the interactions between immune and bone cells should lead to targeted therapeutic strategies for diseases that affect either or both systems.en-USResearch Subject Categories::MEDICINE::Morphology, cell biology, pathology::PathologyJournal Article2022-06-29