Fehringer, GordonKraft, PeterPharoah, PaulEeles, RosalindChatterjee, NilanjanSchumacher, FredSchildkraut, JoellenLindström, SaraBrennan, PaulBickeböller, HeikeHoulston, RichardLandi, Maria TeresaCaporaso, NeilRisch, AngelaOlama, Ali Amin AlBerndt, SonjaGiovannucci, EdwardGrönberg, HenrikKote-Jarai, ZsofiaMa, JingMuir, KennethStampfer, MeirStevens, VictoriaWiklund, FredrikWillett, WalterGoode, EllenPermuth, JenniferRisch, HarveyReid, BrettBezieau, StephaneBrenner, HermannChan, AndrewChang-Claude, JennyHudson, ThomasKocarnik, JonathanNewcomb, PollySchoen, RobertSlattery, MarthaWhite, EmilyAdank, MurielAhsan, HabibulAittomäki, KristiinaBaglietto, LauraBlomquist, CarlCanzian, FedericoCzene, Kamilados-Santos-Silva, IsabelEliassen, A. HeatherFigueroa, JonineFlesch-Janys, DieterFletcher, OliviaGarcia-Closas, MontserratGaudet, MiaJohnson, NicholaHall, PerHazra, AditiHein, RebeccaHofman, AlbertHopper, JohnIrwanto, AstridJohansson, MattiasKaaks, RudolfKibriya, MuhammadLichtner, PeterLiu, JianjunLund, EilivMakalic, EnesMeindl, AlfonsMüller-Myhsok, BertramMuranen, TaruNevanlinna, HeliPeeters, PetraPeto, JulianPrentice, RossRahman, NazneenSanchez, Maria JoseSchmidt, DanielSchmutzler, RitaSouthey, MelissaTamimi, RullaTravis, RuthTurnbull, ClareUitterlinden, AndreWang, ZhaomingWhittemore, AliceYang, XiaohongZheng, WeiRafnar, ThorunnGudmundsson, JuliusStacey, SimonStefansson, KariSulem, PatrickChen, Y. AnnTyrer, JonathanChristiani, DavidWei, YongyueShen, HongbingHu, ZhibinShu, Xiao-OuShiraishi, Kouya2019-09-052016Fehringer, G., P. Kraft, P. D. Pharoah, R. A. Eeles, N. Chatterjee, F. R. Schumacher, J. M. Schildkraut, et al. 2016. “Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.” Cancer Research 76 (17): 5103–14. https://doi.org/10.1158/0008-5472.can-15-2980.0008-54721538-7445http://nrs.harvard.edu/urn-3:HUL.InstRepos:41292490Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus atCDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer, and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression.en-USJournal Article2019-09-0510.1158/0008-5472.CAN-15-2980