AIDA and UCP1 Snuggle Up to Prevent Hypothermia

Mills, EvannaXiao, HaopengChouchani, Edward2022-08-312021-03-09Mills, Evanna L., Haopeng Xiao, and Edward T. Chouchani. “AIDA and UCP1 Snuggle up to Prevent Hypothermia.” Nature Cell Biology 23, no. 3 (March 2021): 216–18. https://doi.org/10.1038/s41556-021-00648-3.1465-73921476-4679https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37373126In response to cold stress, mammals release norepinephrine from the sympathetic nervous system to elevate thermogenesis in brown adipose tissue (BAT) in order to maintain body temperature. This study reveals that the protein AIDA connects sympathetic input, reactive oxygen species, and uncoupling protein 1-mediated adaptive thermogenesis in BAT.en-USResearch Subject Categories::NATURAL SCIENCES::Biology::Cell and molecular biology::Cell biologyAIDA and UCP1 Snuggle Up to Prevent HypothermiaJournal Article2022-08-3110.1038/s41556-021-00648-3