Kussell, EdoShakhnovich, Eugene2019-09-271999Kussell, Edo L., and Eugene I. Shakhnovich. 1999. “Analytical Approach to the Protein Design Problem.” Physical Review Letters 83 (21): 4437–40. https://doi.org/10.1103/physrevlett.83.4437.0031-90071079-71141092-0145http://nrs.harvard.edu/urn-3:HUL.InstRepos:41417273We present an analytical method for determining the designability of protein structures. We apply our method to the case of two-dimensional lattice structures, and give a systematic solution for the spectrum of any structure. Using this spectrum, the designability of a structure can be estimated. We outline a hierarchy of structures, from most to least designable, and show that this hierarchy depends on the potential that is used.en-USJournal Article2019-09-2710.1103/PhysRevLett.83.4437