Gottlieb, DanielHek, KarinChen, Ting-hsuWatson, NathanielEiriksdottir, GudnyByrne, EndaCornelis, MarilynWarby, SimonBandinelli, StefaniaCherkas, LynnEvans, DanielGrabe, HansLahti, JariLi, ManLehtimäki, TerhoLumley, ThomasMarciante, KristinPérusse, LouisPsaty, BruceRobbins, JohnTranah, GregoryVink, JacquelineWilk, JemmaStafford, JeanetteBellis, ClaireBiffar, ReinerBouchard, ClaudeCade, BrianCurhan, GaryEriksson, JohanEwert, RalfFerrucci, LuigiFülöp, TiborGehrman, PhilipGoodloe, RobertHarris, TamaraHeath, AndrewHernandez, DenaHofman, AlbertHottenga, Jouke-JanHunter, DavidJensen, MajkenJohnson, AndrewKähönen, MikaKao, LindaKraft, PeterLarkin, EmmaLauderdale, DianeLuik, AnnemarieMedici, MarcoMontgomery, GrantPalotie, AarnoPatel, SanjayPistis, GiorgioPorcu, EleonoraQuaye, LydiaRaitakari, OlliRedline, SusanRimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600Rotter, JeromeSmith, AlbertSpector, TimTeumer, AlexanderUitterlinden, André G.Vohl, Marie-ClaudeWiden, ElisabethWillemsen, GonnekeYoung, TerryZhang, XiaolingLiu, YongmeiBlangero, JohnBoomsma, DorretGudnason, VilmundurHu, FrankMangino, MassimoMartin, NicholasO’Connor, George T.Stone, KatieTanaka, ToshikoViikari, JormaGharib, SinaPunjabi, NareshRäikkönen, KatriVölzke, HenryMignot, EmmanuelTiemeier, Henning2019-08-262015Gottlieb, D J, K Hek, T-h Chen, N F Watson, G Eiriksdottir, E M Byrne, M Cornelis, et al. 2014. “Novel Loci Associated with Usual Sleep Duration: The CHARGE Consortium Genome-Wide Association Study.” Molecular Psychiatry 20 (10): 1232–39. https://doi.org/10.1038/mp.2014.133.1359-41841476-5578http://nrs.harvard.edu/urn-3:HUL.InstRepos:41247264Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the genetic variants influencing this trait. A genome-wide association study (GWAS) of usual sleep duration was conducted using 18 population-based cohorts totaling 47 180 individuals of European ancestry. Genome-wide significant association was identified at two loci. The strongest is located on chromosome 2, in an intergenic region 35- to 80-kb upstream from the thyroid-specific transcription factor PAX8 (lowest P = 1.1 x 10(-9)). This finding was replicated in an African-American sample of 4771 individuals (lowest P = 9.3 x 10(-4)). The strongest combined association was at rs1823125 (P = 1.5 x 10(-10), minor allele frequency 0.26 in the discovery sample, 0.12 in the replication sample), with each copy of the minor allele associated with a sleep duration 3.1 min longer per night. The alleles associated with longer sleep duration were associated in previous GWAS with a more favorable metabolic profile and a lower risk of attention deficit hyperactivity disorder. Understanding the mechanisms underlying these associations may help elucidate biological mechanisms influencing sleep duration and its association with psychiatric, metabolic and cardiovascular disease.en-USJournal Article2019-08-2610.1038/mp.2014.133