Bihl, FlorianNarayan, MurliChisholm, John V. IIIHenry, Leah M.Suscovich, Todd J.Brown, Elizabeth E.Welzel, Tania M.Kaufmann, Daniel E.Zaman, Tauheed M.Dollard, SheilaMartin, Jeff N.Wang, FredScadden, David T.Kaye, Kenneth M.Brander, Christian2019-10-142007Bihl, F., M. Narayan, J. V. Chisholm, L. M. Henry, T. J. Suscovich, E. E. Brown, T. M. Welzel, et al. 2007. “Lytic and Latent Antigens of the Human Gammaherpesviruses Kaposi’s Sarcoma-Associated Herpesvirus and Epstein-Barr Virus Induce T-Cell Responses with Similar Functional Properties and Memory Phenotypes.” Journal of Virology 81 (9): 4904–8. doi:10.1128/JVI.02509-06.0022-538X1070-63211098-5514http://nrs.harvard.edu/urn-3:HUL.InstRepos:41543021The cellular immunity against Kaposils sarcoma-associated herpesvirus (KSHV) is poorly characterized and has not been compared to T-cell responses against other human herpesviruses. Here, novel and dominant targets of KSHV-specific cellular immunity are identified and compared to T cells specific for lytic and latent antigens in a second human gammaherpesvirus, Epstein-Barr virus. The data identify a novel HILA-B57- and HLA-B58-restricted epitope in the Orf57 protein and show consistently close parallels in immune phenotypes and functional response patterns between cells targeting lytic or latent KSHV- and EBV-encoded antigens, suggesting common mechanisms in the induction of these responses.en-USJournal Article2019-10-1410.1128/JVI.02509-06