Wang, ZeFernández-Seara, MaríaAlsop, DavidLiu, Wen-ChingFlax, Judy F.Benasich, April A.Detre, John A.2022-04-222008-02Wang, Ze, María Fernández-Seara, David Alsop, Wen-Ching Liu, Judy F. Flax, April A. Benasich, John A. Detre. "Assessment of functional development in normal infant brain using arterial spin labeled perfusion MRI." NeuroImage 39, no. 3 (2008): 973-978. DOI: 10.1016/j.neuroimage.2007.09.0451053-8119https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37371447Arterial spin labeled (ASL) perfusion MRI provides a noninvasive approach for longitudinal imaging of regional brain function in infants. In the present study, continuous ASL (CASL) perfusion MRI was carried out in normally developing 7- and 13-month old infants while asleep without sedation. The 13-month infant group showed an increase (P<0.05) of relative CBF in frontal regions as compared to the 7-month group using a region of interest based analysis. Using a machine-learning algorithm to automatically classify the relative CBF maps of the two infant groups, a significant (P<0.05, permutation testing) regional CBF increase was found in the hippocampi, anterior cingulate, amygdalae, occipital lobes, and auditory cortex in the 13-month old infants. These results are consistent with current understanding of infant brain development and demonstrate the feasibility of using perfusion MRI to noninvasively monitor developing brain function.en-USCognitive NeuroscienceNeurologyJournal Article2022-04-2210.1016/j.neuroimage.2007.09.045