Demontis, FabioPiccirillo, RosannaGoldberg, AlfredPerrimon, Norbert2022-07-052013-12Demontis, Fabio, Rosanna Piccirillo, Alfred Goldberg, Norbert Perrimon. "The Influence of Skeletal Muscle on Systemic Aging and Lifespan." Aging Cell 12, no. 6 (2013): 943-949. DOI: 10.1111/acel.121261474-97181474-9726https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37372466Epidemiological studies in humans suggest that skeletal muscle aging is a risk factor for the development of several age-related diseases such as metabolic syndrome, cancer, Alzheimer’s disease, and Parkinson’s disease. Here we review recent studies in mammals and Drosophila highlighting how nutrient- and stress-sensing in skeletal muscle can influence lifespan and overall aging of the organism. In addition to exercise and indirect effects of muscle metabolism, growing evidence suggests that muscle-derived growth factors and cytokines, known as myokines, modulate systemic physiology. Myokines may influence the progression of age-related diseases and contribute to the inter-tissue communication that underlies systemic aging.en-USResearch Subject Categories::NATURAL SCIENCES::Biology::Cell and molecular biology::Cell biologyResearch Subject Categories::MEDICINE::Dermatology and venerology,clinical genetics, internal medicine::Internal medicine::Geriatrics and medical gerontologyJournal Article2022-07-0510.1111/acel.12126