Ambrosio, LindaMahowald, Anthony P.Perrimon, Norbert2021-04-161989Ambrosio, Linda, Anthony Mahowald, Norbert Perrimon. 1989. l(1)pole hole is required maternally for pattern formation in the terminal regions of the embryo. Development 106, no. 1:145-58.https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37367284Maternal expression of the l(l)pole hole (l(l)ph) gene product is required for the development of the Drosophila embryo. When maternal l(l)ph activity is ab- sent, alterations in the embryonic fate map occur as visualized by the expression of segmentation genes fushi- tarazu and engrailed. If both maternal and zygotic activity is absent, embryos degenerate around 7h of development. If only maternal activity is missing, em- bryos complete embryogenesis and show deletions of both anterior and posterior structures. Anteriorly, structures originating from labral and acron head regions are missing. Posteriorly, abdominal segments A8, 9 and 10, the telson and the proctodeum are missing. Similar pattern deletions are observed in embryos de- rived from the terminal class of female sterile mutations. Thus, the maternal l(l)ph+ gene product is required for the establishment of cell identities at the anterior and posterior poles of the Drosophila embryo.en-USJournal Article2021-04-16