Peng, Lee F.Kim, Sun SukMatchacheep, SirinyaLei, XiaoguangSu, ShunLin, WenyuRunguphan, WeerawatChoe, Won-HyeokSakamoto, NaoyaIkeda, MasanoriKato, NobuyukiBeeler, Aaron B.Porco, John A. Jr.Schreiber, Stuart L.Chung, Raymond T.2019-10-032007Peng, L. F., S. S. Kim, S. Matchacheep, X. Lei, S. Su, W. Lin, W. Runguphan, et al. 2007. “Identification of Novel Epoxide Inhibitors of Hepatitis C Virus Replication Using a High-Throughput Screen.” Antimicrobial Agents and Chemotherapy 51 (10): 3756–59. https://doi.org/10.1128/aac.00233-07.0066-48041098-6596http://nrs.harvard.edu/urn-3:HUL.InstRepos:41467430Using our high-throughput hepatitis C replicon assay to screen a library of over 8,000 novel diversity-oriented synthesis (DOS) compounds, we identified several novel compounds that regulate hepatitis C virus (HCV) replication, including two libraries of epoxides that inhibit HCV replication (best 50% effective concentration, < 0.5 mu M). We then synthesized an analog of these compounds with optimized activity.en-USJournal Article2019-10-0310.1128/AAC.00233-07