Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning

Koblan, LukeArbab, MandanaShen, MaxHussmann, Jeffrey A.Anzalone, AndrewDoman, JordanNewby, GregoryYang, DianMok, BeverlyReplogle, Joseph M.Xu, AlbertSisley, Tyler A.Weissman, Jonathan S.Adamson, BrittanyLiu, David2022-02-172021-06-28Koblan, Luke, Mandana Arbab, Max Shen, Jeffrey A. Hussmann, Andrew Anzalone, Jordan Doman, Gregory Newby et al. "Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning." Nature Biotechnology 39, no. 11 (2021): 1414-1425. DOI: 10.1038/s41587-021-00938-z1087-01561546-1696https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37370839en-USBiomedical EngineeringMolecular MedicineApplied Microbiology and BiotechnologyBioengineeringBiotechnologyEfficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learningJournal Article2022-02-1710.1038/s41587-021-00938-z