Dillon, DanielPizzagalli, Diego2009-07-292007Dillon, Daniel G., and Diego A. Pizzagalli. 2007. Inhibition of action, thought, and emotion: A selective neurobiological review. Applied and Preventive Psychology 12, no. 3: 99-114.0962-1849http://nrs.harvard.edu/urn-3:HUL.InstRepos:3200668The neural bases of inhibitory function are reviewed, covering data from paradigms assessing inhibition of motor responses (antisaccade, go/nogo, stop-signal), cognitive sets (e.g., Wisconsin Card Sort Test), and emotion (fear extinction). The frontal cortex supports performance on these paradigms, but the specific neural circuitry varies: response inhibition depends upon fronto-basal ganglia networks, inhibition of cognitive sets is supported by orbitofrontal cortex, and retention of fear extinction reflects ventromedial prefrontal cortex-amygdala interactions. Inhibition is thus neurobiologically heterogeneous, although right ventrolateral prefrontal cortex may support a general inhibitory process. Dysfunctions in these circuits may contribute to psychopathological conditions marked by inhibitory deficits.en-USfMRIpsychopathologyemotionexecutive functioninhibition10.1016/j.appsy.2007.09.004