A One-Step Synthesis of Pseudoephedrine Glycinamide, a Versatile Precursor for the Synthesis of a-Amino Acids

Myers, AndrewYoon, TaeyoungGleason, James L.2011-02-151995Myers, Andrew G., Taeyoung Yoon, and James L. Gleason.0040-4039http://nrs.harvard.edu/urn-3:HUL.InstRepos:4725866Both enantiomers of a pseudoephedrine glycinamide [(+)- or (-)-1] were synthesized by either of two procedures: (1) a standard two-step coupling of N-Boc-Gly with pseudoephedrine followed by deprotection, or (2) a more economical one-step coupling reaction of Gly-OMe with pseudoephedrine mediated by LiCl and base.en-USone-step synthesisalpha amino acidglycinamidepseudoephedrineA One-Step Synthesis of Pseudoephedrine Glycinamide, a Versatile Precursor for the Synthesis of a-Amino Acids10.1016/0040-4039(95)00820-3