Enantioselective Synthesis of (+)-Cephalostatin 1

Fortner, KevinKato, DarrylTanaka, YoshikiShair, Matthew2012-01-192010Fortner, Kevin, Darryl Kato, Yoshiki Tanaka, Matthew David Shair. 2010. Enantioselective Synthesis of (+)-Cephalostatin 1. Journal of the American Chemical Society 132(1): 275-280.0002-7863http://nrs.harvard.edu/urn-3:HUL.InstRepos:7982718This Article describes an enantioselective synthesis of cephalostatin 1. Key steps of this synthesis are a unique methyl group selective allylic oxidation, directed C−H hydroxylation of a sterol at C12, Au(I)-catalyzed 5-endo-dig cyclization, and a kinetic spiroketalization.en-USnatural producttotal synthesisantiproliferativecephalostatinEnantioselective Synthesis of (+)-Cephalostatin 1Journal Article2012-01-1910.1021/ja906996c