Wang, QiuSchreiber, Stuart2010-10-062009Wang, Qiu, and Stuart L. Schreiber. 2009. Copper-mediated amidation of heterocyclic and aromatic C−H bonds. Organic Letters 11(22): 5178-5180.1523-7060http://nrs.harvard.edu/urn-3:HUL.InstRepos:4459010A copper-mediated aerobic coupling reaction enables direct amidation of heterocycles or aromatics having weakly acidic C−H bonds with a variety of nitrogen nucleophiles. These reactions provide efficient access to many biologically important skeletons, including ones with the potential to serve as inhibitors of HMTs.en-USJournal Article2010-10-0610.1021/ol902079g