Zhu, XiaopengZhang, XinminChen, RunshengManrai, Arjun KSong, Jun SJohnson, W. EvanLi, WeiLiu, XiaoleLiu, Jun2010-10-072007Song, Jun S., W. Evan Johnson, Xiaopeng Zhu, Xinmin Zhang, Wei Li, Arjun K. Manrai, Jun S. Liu, Runsheng Chen, and X. Shirley Liu. 2007. Model-based analysis of two-color arrays (MA2C). Genome Biology 8(8): R178.1465-6906http://nrs.harvard.edu/urn-3:HUL.InstRepos:4461117A novel normalization method based on the GC content of probes is developed for two-color tiling arrays. The proposed method, together with robust estimates of the model parameters, is shown to perform superbly on published data sets. A robust algorithm for detecting peak regions is also formulated and shown to perform well compared to other approaches. The tools have been implemented as a stand-alone Java program called MA2C, which can display various plots of statistical analysis for quality control.en-USJournal Article2010-10-0710.1186/gb-2007-8-8-r178