Lorang, JanetKing, Randall2011-03-182005Lorang, Janet and Randall W. King. 2005. Cytological profiling: providing more haystacks for chemists' needles. Genome Biology 6(8): 228.1465-6906http://nrs.harvard.edu/urn-3:HUL.InstRepos:4743815Conventional high-throughput ‘chemical genetic’ screening seeks to identify small-molecule inhibitors of a specific protein or pathway. A recent study describes how unbiased screening of cellular morphology, followed by affinity purification to identify targets of compounds with interesting effects, can lead to the identification of novel inhibitors.en-USBiotechnologyApplied MicrobiologyGeneticsHeredityJournal Article2011-03-1810.1186/gb-2005-6-8-228