Lieberman, Linda AdelleTsokos, George2011-06-142010Lieberman, Linda A., and George C. Tsokos. 2010. The IL-2 defect in systemic lupus erythematosus disease has an expansive effect on host immunity. Journal of Biomedicine and Biotechnology 2010: 740619.1110-7243http://nrs.harvard.edu/urn-3:HUL.InstRepos:4911702IL-2 production is decreased in systemic lupus erythematosus (SLE) patients and affects T cell function and other aspects of host immunity. Transcription factors regulating IL-2 production behave aberrantly in SLE T cells. In addition to IL-2 dysregulation, other IL-2 family members (IL-15 and IL-21) are abnormally expressed in SLE. Decreased IL-2 production in SLE patients leads to many immune defects such as decreased Treg production, decreased activation-induced cell death (AICD), and decreased cytotoxicity. IL-2 deficiency results in systemic dysregulation of host immune responses in patients suffering from SLE disease.en-USJournal Article2011-06-1410.1155/2010/740619