Hegreness, MatthewKishony, Roy2013-10-172007Hegreness, Matthew and Roy Kishony. 2007. Analysis of genetic systems using experimental evolution and whole-genome sequencing. Genome Biology 8(1): 201.1465-6906http://nrs.harvard.edu/urn-3:HUL.InstRepos:11181063The application of whole-genome sequencing to the study of microbial evolution promises to reveal the complex functional networks of mutations that underlie adaptation. A recent study of parallel evolution in populations of Escherichia coli shows how adaptation involves both functional changes to specific proteins as well as global changes in regulation.en-USFrom Thomson ISI Web of Knowledge Keywords Plus:Term Experimental EvolutionEscherichia-Coli PopulationsMutation RateCaenorhabditis-ElegansBeneficial MutationsClonal InterferenceAdaptive Evolution20,000 GenerationsParallel ChangesDNAJournal Article2013-10-1710.1186/gb-2007-8-1-201