Baird, Heather AMarozsan, Andre JLederman, Michael MLanday, AlanMildvan, DonnaKuritzkes, DanielKessler, Harold AArts, Eric J2012-02-032005Baird, Heather A, Andre J Marozsan, Michael M Lederman, Alan Landay, Donna Mildvan, Daniel R Kuritzkes, Harold A Kessler, and Eric J Arts. 2005. Monitoring processed, mature Human Immunodeficiency Virus type 1 particles immediately following treatment with a protease inhibitor-containing treatment regimen. AIDS Research and Therapy 2: 2.1742-6405http://nrs.harvard.edu/urn-3:HUL.InstRepos:8097015Protease inhibitors (PIs) block HIV-1 maturation into an infectious virus particle by inhibiting the protease processing of gag and gag-pol precursor proteins. We have used a simple anti-HIV-1 p24 Western blot to monitor the processing of p55\(^{\text{gag}}\) precursor into the mature p24 capsid immediately following the first dosage of a PI-containing treatment regimen. Evidence of PI activity was observed in plasma virus as early as 72 hours post treatment-initiation and was predictive of plasma viral RNA decrease at 4 weeks.en-USJournal Article2012-02-0310.1186/1742-6405-2-2