Bartoli, Carlo R.Wellenius, Gregory A.Diaz, EdgarLawrence, JoyCoull, BrentAkiyama, IchiroLee, Lani M.Okabe, KazunoriVerrier, RichardGodleski, John2012-01-082008Bartoli, Carlo R., Gregory A. Wellenius, Edgar A. Diaz, Joy Lawrence, Brent A. Coull, Ichiro Akiyama, Lani M. Lee, Kazunori Okabe, Richard L. Verrier, and John J. Godleski. 2009. Mechanisms of inhaled fine particulate air pollution–induced arterial blood pressure changes. Environmental Health Perspectives 117(3): 361-366.0091-6765http://nrs.harvard.edu/urn-3:HUL.InstRepos:7349719Background: Epidemiologic studies suggest a positive association between fine particulate matter and arterial blood pressure, but the results have been inconsistent. Objectives: We investigated the effect of ambient particles on systemic hemodynamics during a 5-hr exposure to concentrated ambient air particles (CAPs) or filtered air (FA) in conscious canines. Methods: Thirteen dogs were repeatedly exposed via permanent tracheostomy to CAPs (358.1 ± 306.7 μg/m\(^3\), mean ± SD) or FA in a crossover protocol (55 CAPs days, 63 FA days). Femoral artery blood pressure was monitored continuously via implanted telemetry devices. We measured baroreceptor reflex sensitivity before and after exposure in a subset of these experiments (n = 10 dogs, 19 CAPs days, 20 FA days). In additional experiments, we administered α-adrenergic blockade before exposure (n = 8 dogs, 16 CAPs days, 15 FA days). Blood pressure, heart rate, rate–pressure product, and baroreceptor reflex sensitivity responses were compared using linear mixed-effects models. Results: CAPs exposure increased systolic blood pressure (2.7 ± 1.0 mmHg, p = 0.006), diastolic blood pressure (4.1 ± 0.8 mmHg; p < 0.001), mean arterial pressure (3.7 ± 0.8 mmHg; p < 0.001), heart rate (1.6 ± 0.5 bpm; p < 0.001), and rate–pressure product (539 ± 110 bpm × mmHg; p < 0.001), and decreased pulse pressure (−1.7 ± 0.7 mmHg, p = 0.02). These changes were accompanied by a 20 ± 6 msec/mmHg (p = 0.005) increase in baroreceptor reflex sensitivity after CAPs versus FA. After α-adrenergic blockade, responses to CAPs and FA no longer differed significantly. Conclusions: Controlled exposure to ambient particles elevates arterial blood pressure. Increased peripheral vascular resistance may mediate these changes, whereas increased baroreceptor reflex sensitivity may compensate for particle-induced alterations in blood pressure.en-USα-adrenergic receptorsbaroreceptorsblood pressurehypertensionparticulate air pollutionJournal Article2012-01-0810.1289/ehp.11573