Wee, Christina CDavis, RogerHamel, Mary2011-05-032008Wee, Christina C., Roger B. Davis, and Mary Beth Hamel. 2008. Comparing the SF-12 and SF-36 health status questionnaires in patients with and without obesity. Health and Quality of Life Outcomes 6: 11.1477-7525http://nrs.harvard.edu/urn-3:HUL.InstRepos:4881564Objective: To assess how well the SF-36, a well-validated generic quality of life (QOL) instrument, compares with its shorter adaptation, the SF-12, in capturing differences in QOL among patients with and without obesity. Methods: We compared the correlation between the physical (PCS) and mental (MCS) component summary measures of the SF-12 and SF-36 among 356 primary care patients using Pearson coefficients (r) and conducted linear regression models to see how these summary measures captures the variation across BMI. We used model R\(^{2}\) to assess qualitatively how well each measure explained the variation across BMI. Results: Correlations between SF-12 and SF-36 were higher for the PCS in obese (r = 0.89) compared to overweight (r = 0.73) and normal weight patients (r = 0.75), p < 0.001, but were similar for the MCS across BMI. Compared to normal weight patients, obese patients scored 8.8 points lower on the PCS-12 and 5.7 points lower on the PCS-36 after adjustment for age, sex, and race; the model R\(^{2}\) was higher with PCS-12 (R\(^{2}\) = 0.22) than with PCS-36 (R\(^{2}\) = 0.16). BMI was not significantly associated with either the MCS-12 or MCS-36. Conclusion: The SF-12 correlated highly with SF-36 in obese and non-obese patients and appeared to be a better measure of differences in QOL associated with BMI.en-USJournal Article2011-05-0310.1186/1477-7525-6-11