O’Neill, Marie S.Park, Sung KyunVokonas, PantelSparrow, DavidSchwartz, Joel2011-05-012004Park, Sung Kyun, Marie S. O'Neill, Pantel S. Vokonas, David Sparrow, and Joel Schwartz. 2005. Effects of air pollution on heart rate variability: the VA Normative Aging Study. Environmental Health Perspectives 113(3): 304-309.0091-6765http://nrs.harvard.edu/urn-3:HUL.InstRepos:4879856Reduced heart rate variability (HRV), a marker of poor cardiac autonomic function, has been associated with air pollution, especially fine particulate matter [< 2.5 μm in aerodynamic diameter (PM\(_{2.5}\))]. We examined the relationship between HRV [standard deviation of normal-to-normal intervals (SDNN), power in high frequency (HF) and low frequency (LF), and LF:HF ratio] and ambient air pollutants in 497 men from the Normative Aging Study in greater Boston, Massachusetts, seen between November 2000 and October 2003. We examined 4-hr, 24-hr, and 48-hr moving averages of air pollution (PM\(_{2.5}\), particle number concentration, black carbon, ozone, nitrogen dioxide, sulfur dioxide, carbon monoxide). Controlling for potential confounders, HF decreased 20.8% [95% confidence interval (CI), 4.6–34.2%] and LF:HF ratio increased 18.6% (95% CI, 4.1–35.2%) per SD (8 μg/m\(^3\)) increase in 48-hr PM\(_{2.5}\). LF was reduced by 11.5% (95% CI, 0.4–21.3%) per SD (13 ppb) increment in 4-hr O\(_3\). The associations between HRV and PM\(_{2.5}\) and O\(_3\) were stronger in people with ischemic heart disease (IHD) and hypertension. The associations observed between SDNN and LF and PM\(_{2.5}\) were stronger in people with diabetes. People using calcium-channel blockers and beta-blockers had lower associations between O\(_3\) and PM\(_{2.5}\) with LF. No effect modification by other cardiac medications was found. Exposures to PM\(_{2.5}\) and O\(_3\) are associated with decreased HRV, and history of IHD, hypertension, and diabetes may confer susceptibility to autonomic dysfunction by air pollution.en-USair pollutiondiabetesheart rate variabilityhypertensionischemic heart diseaseozonePM\(_{2.5}\)Journal Article2011-05-0110.1289/ehp.7447