Paré, GuillaumeKellogg, MarkBadola, SunitaMiletich, Joseph P.Gibson, GregChasman, DanielZee, Robert Yuk LungRifai, NaderRidker, Paul2011-09-132008Pare, Guillaume, Mark Kellogg, Sunita Badola, Joseph P. Miletich, Greg Gibson, Daniel Ian Chasman, Robert Yuk Lung Zee, Nader Rifai, and Paul M. Ridker. 2008. Novel Association of ABO Histo-blood Group Antigen with Soluble ICAM-1: Results of a Genome-wide Association Study of 6,578 Women. PLoS Genetics 4 (7): e1000118.1553-7390http://nrs.harvard.edu/urn-3:HUL.InstRepos:5129837While circulating levels of soluble Intercellular Adhesion Molecule 1 (sICAM-1) have been associated with diverse conditions including myocardial infarction, stroke, malaria, and diabetes, comprehensive analysis of the common genetic determinants of sICAM-1 is not available. In a genome-wide association study conducted among 6,578 participants in the Women's Genome Health Study, we find that three SNPs at the ICAM1 (19p13.2) locus (rs1799969, rs5498 and rs281437) are non-redundantly associated with plasma sICAM-1 concentrations at a genome-wide significance level (P<5×10\(^{−8}\)), thus extending prior results from linkage and candidate gene studies. We also find that a single SNP (rs507666, P = 5.1×10\(^{−29}\)) at the ABO (9q34.2) locus is highly correlated with sICAM-1 concentrations. The novel association at the ABO locus provides evidence for a previously unknown regulatory role of histo-blood group antigens in inflammatory adhesion processes.en-USHematologyCardiovascular disordersCardiovascular diseases in womenMyocardial infarctionGenetics and genomicsComplex traitsGenetics of the immune systemBlood transfusionInfectious diseasesTropical and travel-associated diseasesJournal Article2011-09-1310.1371/journal.pgen.1000118