Gnerre, SanteLander, EricLindblad-Toh, KerstinJaffe, David B2011-11-012009Gnerre, Sante, Eric S Lander, Kerstin Lindblad-Toh, and David B Jaffe. 2009. Assisted assembly: how to improve a de novo genome assembly by using related species. Genome Biology 10(8): R88.1465-6906http://nrs.harvard.edu/urn-3:HUL.InstRepos:5334258We describe a new assembly algorithm, where a genome assembly with low sequence coverage, either throughout the genome or locally, due to cloning bias, is considerably improved through an assisting process via a related genome. We show that the information provided by aligning the whole-genome shotgun reads of the target against a reference genome can be used to substantially improve the quality of the resulting assembly.en-USJournal Article2011-11-0110.1186/gb-2009-10-8-r88