Benoist, ChristopheMathis, Diane2011-11-092000Benoist, Christophe, and Diane Mathis. 2000. A revival of the B cell paradigm for rheumatoid arthritis pathogenesis? Arthritis Research 2(2): 90-94.1465-9905http://nrs.harvard.edu/urn-3:HUL.InstRepos:5343539Dominant paradigms for the understanding of rheumatoid arthritis (RA) pathogenesis have changed over the years. A predominant role of B lymphocytes, and perhaps of the rheumatoid factor they produced, was initially invoked. In more recent years, recognition of antigens in the joint by T cells sparking an inflammatory cascade has been a more favored interpretation. Here, we re-examine some of the arguments that underpin this proposed role of joint T cells, in light of recent results from transgenic mice in which a self-reactive T-cell receptor provokes disease, but from outside the joint and indirectly via B lymphocytes and immunoglobulins.en-USB lymphocyteimmunoglobulinmajor histocompatibility complexT lymphocytetransgenicJournal Article2011-11-0910.1186/ar73