Hardwick, Kevin GShah, Jagesh2011-04-262010Hardwick, Kevin G., and Jagesh V. Shah. 2010. Spindle checkpoint silencing: ensuring rapid and concerted anaphase onset. F1000 Biology Reports 2: 55.1757-594Xhttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4875877The spindle checkpoint delays anaphase onset in the presence of defective kinetochore-microtubule attachments. Such delays can last for just a few minutes or several hours, but very shortly after all chromosomes achieve bi-orientation, a remarkably synchronous anaphase ensues. We are beginning to understand the pathways involved in silencing spindle checkpoint signals and subsequent activation of the anaphase-promoting complex. Here, we review recent advances made in our understanding of the molecular mechanisms regulating this critical cell cycle transition.en-USJournal Article2011-04-2610.3410/B2-55