Locasale, Jason WeiCantley, Lewis C.2011-04-082010Locasale, Jason W., and Lewis C. Cantley. 2010. Altered metabolism in cancer. BMC Biology 8: 88.1741-7007http://nrs.harvard.edu/urn-3:HUL.InstRepos:4817633Cancer cells have different metabolic requirements from their normal counterparts. Understanding the consequences of this differential metabolism requires a detailed understanding of glucose metabolism and its relation to energy production in cancer cells. A recent study in BMC Systems Biology by Vasquez et al. developed a mathematical model to assess some features of this altered metabolism. Here, we take a broader look at the regulation of energy metabolism in cancer cells, considering their anabolic as well as catabolic needs. See research article: http://www.biomedcentral.com/1752-0509/4/58/en-USJournal Article2011-04-0810.1186/1741-7007-8-88