Yıldırım, Muhammed AVidal, Marc2011-03-222008Yıldırım, Muhammed A., and Marc Vidal. 2008. Systems engineering to systems biology. Molecular Systems Biology 4: 185.1744-4292http://nrs.harvard.edu/urn-3:HUL.InstRepos:4750534No abstract provided. First paragraph: The ‘bottom-up’ approach to systems biology entails quantitatively studying complex biological processes by analyzing their molecular components. A converse system biology approach is to infer properties of biological systems in a ‘top-down’ fashion, using a variety of network reverse engineering methods, data-driven modeling and data integration strategies. Application of a top-down approach to the quantitative biology of a small size system is however less common. In a recent publication, Mettetal et al (2008) have insightfully applied such a strategy to successfully decode critical properties of osmo-adaptation in the yeast Saccharomyces cerevisiae.en-USJournal Article2011-03-2210.1038/msb.2008.22