Boes, AaronGrafft, Amanda HornadayJoshi, CharutaChuang, Nathaniel ANopoulos, PegAnderson, Steven W2013-02-142011Boes, Aaron D., Amanda Hornaday Grafft, Charuta Joshi, Nathaniel A. Chuang, Peg Nopoulos, and Steven W. Anderson. 2011. Behavioral effects of congenital ventromedial prefrontal cortex malformation. BMC Neurology 11:151.1471-2377http://nrs.harvard.edu/urn-3:HUL.InstRepos:10288947Background: A detailed behavioral profile associated with focal congenital malformation of the ventromedial prefrontal cortex (vmPFC) has not been reported previously. Here we describe a 14 year-old boy, B.W., with neurological and psychiatric sequelae stemming from focal cortical malformation of the left vmPFC. Case Presentation: B.W.'s behavior has been characterized through extensive review Patience of clinical and personal records along with behavioral and neuropsychological testing. A central feature of the behavioral profile is severe antisocial behavior. He is aggressive, manipulative, and callous; features consistent with psychopathy. Other problems include: egocentricity, impulsivity, hyperactivity, lack of empathy, lack of respect for authority, impaired moral judgment, an inability to plan ahead, and poor frustration tolerance. Conclusions: The vmPFC has a profound contribution to the development of human prosocial behavior. B.W. demonstrates how a congenital lesion to this cortical region severely disrupts this process.en-USJournal Article2013-02-1410.1186/1471-2377-11-151