Kim, JayoungFreeman, Michael R.2013-02-112011Kim, Jayoung, and Michael R. Freeman. 2011. Antiproliferative factor signaling and interstitial cystitis/painful bladder syndrome. International Neurourology Journal 15(4): 184-191.2093-4777http://nrs.harvard.edu/urn-3:HUL.InstRepos:10288493A unique glycopeptide, antiproliferative factor (APF), has been suggested as a urinary biomarker and potential mediator of long-term bladder disorder Interstitial Cystitis/Painful Bladder Syndrome. There is no known cause for this disease. Several mechanistic approaches have been employed to address the underlying mechanism whereby APF regulates cellular responses in the bladder epithelium. A summary of recent literature is provided, and is focused on signal transduction pathways and networks that are responsive to APF.en-UShuman antiproliferative factor APFinterstitial cystitissignal transductionJournal Article2013-02-1110.5213/inj.2011.15.4.184