Chan, Ying KaiHuang, I-ChuehFarzan, Michael2013-02-252012Chan, Ying Kai, I-Chueh Huang, and Michael Farzan. 2012. IFITM proteins restrict antibody-dependent enhancement of dengue virus infection. PLoS ONE 7(3): e34508.1932-6203http://nrs.harvard.edu/urn-3:HUL.InstRepos:10344717Interferon-inducible transmembrane (IFITM) proteins restrict the entry processes of several pathogenic viruses, including the flaviviruses West Nile virus and dengue virus (DENV). DENV infects cells directly or via antibody-dependent enhancement (ADE) in Fc-receptor-bearing cells, a process thought to contribute to severe disease in a secondary infection. Here we investigated whether ADE-mediated DENV infection bypasses IFITM-mediated restriction or whether IFITM proteins can be protective in a secondary infection. We observed that IFITM proteins restricted ADE-mediated and direct infection with comparable efficiencies in a myelogenous leukemia cell line. Our data suggest that IFITM proteins can contribute to control of secondary DENV infections.en-USBiologyImmunologyImmunityMicrobiologyVirologyViral ClassificationMedicineInfectious DiseasesNeglected Tropical DiseasesViral DiseasesJournal Article2013-02-2510.1371/journal.pone.0034508