Baker, MeghanWilson, DouglasWallengren, KristinaSandgren, AndreasIartchouk, OlegBroodie, Nisha MoniqueGoonesekera, Sunali D.Sabeti, PardisMurray, Megan2012-11-132012Baker, Meghan Ann, Douglas Wilson, Kristina Wallengren, Andreas Sandgren, Oleg Iartchouk, Nisha Broodie, Sunali D. Goonesekra, Pardis C Sabeti, and Megan B. Murray. 2012. Polymorphisms in the gene that encodes the iron transport protein ferroportin 1 influence susceptibility to suberculosis. Journal of Infectious Disease 205(7): 1043-1047.0022-18991537-6613http://nrs.harvard.edu/urn-3:HUL.InstRepos:9891821Background: We studied the association between iron intake and polymorphisms in the iron transporter gene, SLC40A1, and the risk of tuberculosis. Methods: We compared iron intake, the frequency of SLC40A1 mutations, and interactions between these variables among 98 TB patients and 125 controls in Kwazulu-Natal, South Africa. Results: Four SLC40A1 SNPs were associated with an increased risk of tuberculosis and one with reduced risk. We also found a gene-environment interaction for four non-exonic SNPs and iron intake. Conclusions: This pilot study demonstrated an association between polymorphisms in SLC40A1 and tuberculosis and provided evidence for an interaction between dietary iron and SLC40A1.en-USSLC40A1ferroportinFPN1tuberculosismycobacteriumirongeneticsingle nucleotide polymorphismgene-environmentJournal Article2012-11-1310.1093/infdis/jis026