Scott, Robert ALagou, VasilikiWelch, Ryan PWheeler, EleanorMontasser, May ELuan, Jian’anMägi, ReedikStrawbridge, Rona JRehnberg, EmilGustafsson, StefanKanoni, StavroulaRasmussen-Torvik, Laura JYengo, LoïcLecoeur, CecileShungin, DmitrySanna, SerenaSidore, CarloJohnson, Paul C DJukema, J WouterJohnson, TobyMahajan, AnubhaVerweij, NiekThorleifsson, GudmarHottenga, Jouke-JanShah, SoniaSmith, Albert VSennblad, BengtGieger, ChristianSalo, PerttuPerola, MarkusTimpson, Nicholas JEvans, David MPourcain, Beate StWu, YingAndrews, Jeanette SHui, JennieBielak, Lawrence FZhao, WeiHorikoshi, MomokoNavarro, PauIsaacs, AaronO’Connell, Jeffrey RStirrups, KathleenVitart, VeroniqueHayward, CarolineEsko, TönuMihailov, EvelinFraser, Ross MFall, ToveVoight, Benjamin FRaychaudhuri, SoumyaChen, HanLindgren, Cecilia MMorris, Andrew PRayner, Nigel WRobertson, NeilRybin, DenisLiu, Ching-TiBeckmann, Jacques SWillems, Sara MChines, Peter SJackson, Anne UKang, Hyun MinStringham, Heather MSong, KijoungTanaka, ToshikoPeden, John FGoel, AnujHicks, Andrew AAn, PingMüller-Nurasyid, MartinaFranco-Cereceda, AndersFolkersen, LasseMarullo, LetiziaJansen, HannekeOldehinkel, Albertine JBruinenberg, MarcelPankow, James SNorth, Kari EForouhi, Nita GLoos, Ruth J FEdkins, SarahVarga, Tibor VHallmans, GöranOksa, HeikkiAntonella, MulasNagaraja, RamaiahTrompet, StellaFord, IanBakker, Stephan J LKong, AugustineKumari, MeenaGigante, BrunaHerder, ChristianMunroe, Patricia BCaulfield, MarkAntti, JulaMangino, MassimoSmall, KerrinMiljkovic, IvaLiu, YongmeiAtalay, MustafaKiess, WielandJames, Alan LRivadeneira, FernandoUitterlinden, Andre GPalmer, Colin N ADoney, Alex S FWillemsen, GonnekeSmit, Johannes HCampbell, SusanPolasek, OzrenBonnycastle, Lori LHercberg, SergeDimitriou, MariaBolton, Jennifer LFowkes, Gerard RKovacs, PeterLindström, JaanaZemunik, TatijanaBandinelli, StefaniaWild, Sarah HBasart, Hanneke VRathmann, WolfgangGrallert, HaraldMaerz, WinfriedKleber, Marcus EBoehm, Bernhard OPeters, AnnettePramstaller, Peter PProvince, Michael ABorecki, Ingrid BHastie, Nicholas DRudan, IgorCampbell, HarryWatkins, HughFarrall, MartinStumvoll, MichaelFerrucci, LuigiWaterworth, Dawn MBergman, Richard NCollins, Francis STuomilehto, JaakkoWatanabe, Richard Mde Geus, Eco J CPenninx, Brenda WHofman, AlbertOostra, Ben APsaty, Bruce MVollenweider, PeterWilson, James FWright, Alan FHovingh, G KeesMetspalu, AndresUusitupa, MattiMagnusson, Patrik K EKyvik, Kirsten OKaprio, JaakkoPrice, Jackie FDedoussis, George VDeloukas, PanosMeneton, PierreLind, LarsBoehnke, MichaelShuldiner, Alan Rvan Duijn, Cornelia MMorris, Andrew DToenjes, AnkePeyser, Patricia ABeilby, John PKörner, AntjeKuusisto, JohannaLaakso, MarkkuBornstein, Stefan RSchwarz, Peter E HLakka, Timo ARauramaa, RainerAdair, Linda SSmith, George DaveySpector, Tim DIllig, Thomasde Faire, UlfHamsten, AndersGudnason, VilmundurKivimaki, MikaHingorani, AroonKeinanen-Kiukaanniemi, Sirkka MSaaristo, Timo EBoomsma, Dorret IStefansson, Karivan der Harst, PimDupuis, JoséePedersen, Nancy LSattar, NaveedHarris, Tamara BCucca, FrancescoRipatti, SamuliSalomaa, VeikkoMohlke, Karen LBalkau, BeverleyFroguel, PhilippePouta, AnneliJarvelin, Marjo-RiittaWareham, Nicholas JBouatia-Naji, NabilaMcCarthy, Mark IFranks, Paul WMeigs, JamesTeslovich, Tanya MFlorez, JoseLangenberg, ClaudiaIngelsson, ErikProkopenko, IngaBarroso, Inês2013-05-162012Scott, Robert A, Vasiliki Lagou, Ryan P Welch, Eleanor Wheeler, May E Montasser, Jian’an Luan, Reedik Mägi, et al. 2012. Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nature genetics 44(9): 991-1005.1061-4036http://nrs.harvard.edu/urn-3:HUL.InstRepos:10642219Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have raised the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q < 0.05). Loci influencing fasting insulin showed association with lipid levels and fat distribution, suggesting impact on insulin resistance. Gene-based analyses identified further biologically plausible loci, suggesting that additional loci beyond those reaching genome-wide significance are likely to represent real associations. This conclusion is supported by an excess of directionally consistent and nominally significant signals between discovery and follow-up studies. Functional follow-up of these newly discovered loci will further improve our understanding of glycemic control.en-USJournal Article2013-05-1610.1038/ng.2385